Dr. Urano's Blog

Wolfram: Oxidative Stress and Endoplasmic Reticulum

Is antioxidant good for Wolfram syndrome? Although we don’t have clear scientific evidence at this point, it is possible that antioxidants could be beneficial for Wolfram syndrome patients.

Accumulating evidence in my research group strongly suggests that endoplasmic reticulum (ER) dysfunction can lead to oxidative stress. Oxidative stress means that reactive oxygen species (ROS) exceeds the ability of our body to counteract their harmful effects. Our body has the ability to deal with certain amount of ROS, but if there is too much ROS, it leads to oxidative stress. In theory, antioxidants should be able to mitigate ER stress-mediated oxidative stress and its harmful effects. We are particularly interested in this concept in the context of optic nerve atrophy and neurodegeneration in Wolfram.

We still don’t have clear evidence that antioxidants are beneficial for Wolfram syndrome patients. So I recommend that you consult with your physician if you are interested in taking antioxidants.