I have been trying to create the Endoplasmic Reticulum Disease Center to develop novel treatments for Wolfram syndrome and other diseases associated with ER stress/ER dysfunction. Some forms of early-onset diabetes are associated with ER stress. Some forms of hereditary hearing impairment are associated with Wolfram syndrome 1 gene mutations. Some forms of retinal degeneration are associated with ER dysfunction. By systematically examining these patients and biological samples from them, we can develop novel diagnostics and therapeutics. I could recruit many physicians who can potentially work with me. I will keep you updated about our progress.
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