Wolfram syndrome is characterized by juvenile-onset diabetes, optic nerve atrophy, and neurodegeneration. It seems like that there is a strong link between Type 1 diabetes and Wolfram syndrome, Dysregualted Endoplasmic Reticulum Calcium Homeostasis. If we can control this using a drug, we can potentially treat both diseases. We have a candidate drug and hope to get supports to test this possibility.
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