Currently we are focusing on manipulating cellular calcium (ER calcium) homeostasis using small molecules (i.e., drugs) to delay the progression of Wolfram syndrome. In addition, I want to take another strategy, which is to alleviate cell stress using chemical chaperones. Chemical chaperones are small molecules that can reduce ER stress by stabilizing defective cellular proteins. It is a “crutch” for defective Wolfram proteins in patients with Wolfram syndrome. We may want to combine this strategy with our current strategy.
I hope you will have a wonderful day. Take care, Fumi Urano